The Catholic Church in South Africa is part of the worldwide Catholic Church composed of the Latin Church and 23 Eastern Catholic Churches, of which the South African church is under the spiritual leadership of the Southern African Catholic Bishops Conference and the Pope in Rome. It is made up of 26 dioceses and archdioceses plus an apostolic vicariate.

In 1996, there were approximately 3.3 million Catholics in South Africa, making up 6% of the total South African population. Currently, there are 3.8 million Catholics. 2.7 million are of various black African ethnic groups, such as Zulu, Xhosa, and Sotho. Coloured and white South Africans each account for roughly 300,000.

Roman Catholic evangelization efforts have traditionally focused on Black South Africans. In the 1950s, however, an effort began to evangelize Afrikaans-speakers, who had previously been ignored by Catholic missionaries. Success in the Afrikaans Apostolate remained minimal until the death throes of Apartheid during the mid to late 1980s. As Catholic texts began to be translated into Afrikaans, sympathetic Dutch Reformed pastors, who were defying the traditional anti-Catholicism of their Church, assisted in correcting linguistic errors. By 1996, the majority of Afrikaans-speaking Catholics came from the Coloured community, with a smaller number of Afrikaner converts, most of whom were from professional backgrounds.

Most White South African Catholics are English speakers, and the majority are descended from Irish immigrants. Many others are Portuguese South Africans, many of whom emigrated from Angola and Mozambique after they became independent and disintegrated into civil war during the 1970s. Others are descended from immigrants from other European countries, such as South Africa's Italian community. The proportion of Catholics among the predominantly Calvinist white Afrikaans speakers, or Asian South Africans who are mainly Hindus or Protestant of Indian descent, is extremely small.